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Contact-dependent disruption of the host cell membrane skeleton induced by Trichomonas vaginalis

Fiori, Pier Luigi and Rappelli, Paola and Addis, Maria Filippa and Mannu, Franca Rita and Cappuccinelli, Pietro Antonio (1997) Contact-dependent disruption of the host cell membrane skeleton induced by Trichomonas vaginalis. Infection and Immunity, Vol. 65 (12), p. 5142-5148. eISSN 1098-5522. Article.

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This report presents evidence showing that the pathogenetic process of the protozoan parasite Trichomonas vaginalis involves degradation of the target cell membrane skeleton; spectrin, the most representative protein within this structure, has been identified as the main molecular target. Degradation of the target cell spectrin is accomplished only upon contact with the parasite, and immunochemical and immunofluorescence studies performed with the erythrocyte as a model demonstrate that degradation of the protein takes place before target cell lysis. A preliminary characterization of the effectors involved has led to the identification of a nonsecreted 30-kDa proteinase which is characterized by a high specificity for spectrin. This molecule is suggested as the main effector responsible for cytoskeletal disruption.

Item Type:Article
ID Code:7893
Uncontrolled Keywords:Trichomonas vaginalis, spectrin, cytoskeleton
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:American Society for Microbiology
Deposited On:28 Aug 2012 10:28

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