Meloni, Giorgio and Lai, Andrea and Falchi, Laura and Antuofermo, Elisabetta and Burrai, Giovanni and Dattena, Maria and Bomboi, Giovanni Cristoforo and Floris, Basilio Remo (2012) Preliminary study of effects of anti GnRH vaccine on the germ line in 8 months Sarda rams. In: 10. Congress of Italian Society of Animal Reproduction: SIRA 2012: proceedings, 23-25 May 2012, Tirana, Albania. [S.l.], [s.n.]. p. 40-41. ISBN 978-88-907328-0-5. Conference or Workshop Item.
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Several treatments can change reversibly (high and low temperatures and alteration of testosterone levels) or irreversibly (x-ray and chemotherapy) the structural morphology of the testis with alteration of spermatogenesis. The aim of this study was to evaluate the effects of an anti GnRH vaccine on germinal line and seminiferous epithelium in 8 months Sarda rams. The study was carried out using 10 Sarda rams divided into treated and control group. In both groups scrotal circumference and testosterone levels were measured weekly for 12 weeks and histological samples of the testes were collected. The results showed that scrotal circumferences and testosterone levels decreased in the treated group and the seminiferous tubules appeared depleted of the germinal line compared to the control group. The present study showed that the anti GNRH vaccine can be successfully used in rams to inhibit spermatogenesis.
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