An Overview on different classes of viral entry and Respiratory Syncitial Virus (RSV) fusion inhibitors

Murineddu, Gabriele and Murruzzu, Caterina and Pinna, Gérard Aimé (2010) An Overview on different classes of viral entry and Respiratory Syncitial Virus (RSV) fusion inhibitors. Current Medicinal Chemistry, Vol. 17 (11), p. 1067-1091. ISSN 0929-8673. eISSN 1875-533X. Article.

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Abstract

The therapeutic approach to AIDS is based on the combination of different drugs in the highly active antiretroviral therapy (HAART) regimen. These drugs have a wide variety of side effects, and some strains of HIV can develop resistance: for these reasons new anti-HIV drugs are needed.
In the wide field of anti-HIV medicine this review covers different classes of drugs which inhibit viral entry: in particular the classification of main categories, their mode of action and some new candidates for AIDS therapy are contemplated.
Also covered in this review are respiratory syncytial virus (RSV) fusion inhibitors.

Item Type:	Article
ID Code:	7847
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Aids, viral entry inhibitors, CD4 receptor, coreceptor, CCR5, CXCR4, HIV fusion inhibitors, RSV fusion inhibitors
Subjects:	Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:	001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:	Bentham Science
ISSN:	0929-8673
eISSN:	1875-533X
Deposited On:	26 Jul 2012 08:38

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