Pinna, Gérard Aimé and Murineddu, Gabriele and Murruzzu, Caterina and Zuco, Valentina and Zunino, Franco and Cappelletti, Graziella and Artali, Roberto and Cignarella, Giorgio and Solano, Lucrezia and Villa, Stefania (2009) Synthesis, modelling, and antimitotic properties of tricyclic systems characterised by a 2-(5-Phenyl-1H-pyrrol-3-yl)-1,3,4-oxadiazole moiety. ChemMedChem, Vol. 4 (6), p. 998-1009. eISSN 1860-7187. Article.
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Antitumour activity was observed in a series of tricyclic compounds characterised by a 2-(1H-pyrrol-3-yl)-1,3,4-oxadiazole moiety with various substitutions. Their synthesis and antiproliferative activity toward a panel of human tumour cell lines is described. The most interesting compounds 1 c and 4 c were selected for further evaluation to elucidate their possible mechanism of action.
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