Abstract

Reduced survival of skin fibroblasts in cell cultures and laterations of fibroblast gene products, such as surface antigens HLA2 and HLA9 and a cytoplasmic enzyme, glucose-6-phosphate dehydrogenase, have been recently demonstrated in a patient affected by Werner's syndrome. In order to investigate the morphology of the fibroblasts from patients affected by Werner's syndrome it was decided to study the tubulin system in primary cell cultures. Microtubules are tubular structures, 20-25 nm wide, and are thought to play a significant role in cell morphology and in the regulation of intracellular movements. Fibroblast cultures from normal subjects and from patients affected by Kaposi's sarcoma and by psoriasis were studied as controls.

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