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Indagini immunoistochimiche e biomolecolari per l’evidenziazione di retrovirus JSRV-correlati in carcinomi bronchiolo-alveolari dell’uomo

Rocca, Stefano and Sanna, Maria Paola and Farigu, Serafina and Pirino, Salvatore and Cossu, Antonio and Palmieri, Giuseppe and Lissia, Amelia and Leoni, Antonio (2005) Indagini immunoistochimiche e biomolecolari per l’evidenziazione di retrovirus JSRV-correlati in carcinomi bronchiolo-alveolari dell’uomo. In: 2. Congresso nazionale A.I.P.Vet.: atti, 20-21 Maggio 2005, Lodi, Italia. Milano, AIPVet. p. 27-30. ISSN 1825-2265. Conference or Workshop Item.

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Abstract

The bronchioloalveolar adenocarcinoma was described in several species (human, bovine, ovine and domestic carnivores). Ovine pulmonary adenocarcinoma (OPA) or pulmonary adenomatosis is a contagious carcinoma of sheep caused by an exogenous type D retrovirus denominated also jaagsiekte sheep retrovirus (JSRV). JSRV is responsible of the neoplastic transformation of type II pneumocytes and Clara cells. The human bronchioloalveolar adenocarcinoma (BAC) have histo-morphological features much similar to OPA. We report the study about ten BAC cases and one negative human control (lung). DNA extraction, PCR, sequencing of amplified product, immunohistochemistry and in situ hybridization were performed on all paraffin-embedded samples. Our results demonstrated the presence of JSRVlike sequences in all cases of human bronchiolo-alveolar carcinoma.

Item Type:Conference or Workshop Item (Contribute)
ID Code:7783
Status:Published
Uncontrolled Keywords:Bronchioloalveolar adenocarcinoma, sheep pulmonary adenomatosis, in-situ hybridization, immunohistochemistry
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria
002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche
001 Università di Sassari > 03 Istituti > Anatomia patologica
Publisher:AIPVet
ISSN:1825-2265
Deposited On:16 Jul 2012 09:14

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