titoli, abstracts, parole chiave >>>
LDL S-homocysteinylation decrease in chronic kidney disease patients undergone lipid lowering therapy

Zinellu, Angelo and Sotgia, Salvatore and Pisanu, Elisabetta and Loriga, Giacomina and Deiana, Luca and Satta, Andrea Ercole and Carru, Ciriaco (2012) LDL S-homocysteinylation decrease in chronic kidney disease patients undergone lipid lowering therapy. European Journal of Pharmaceutical Sciences, Vol. 47 (1), p. 117-123. ISSN 0928-0987. Article.

Full text not available from this repository.

DOI: 10.1016/j.ejps.2012.05.006

Abstract

The dyslipidemia control through lipid lowering therapy is one of the targets for the treatment of CKD. By this pilot study we aimed to evaluate the effect of hypolipidemic drugs on the levels of low molecular weight (LMW) thiols bound to LDL in nephropatic patients. We enrolled thirty CKD randomized to receive three different hypolipidemic regimens: simvastatin alone (40 mg/day) or ezetimibe/simvastatin combined therapy (10/20 or 10/40 mg/day). LMW thiols in their reduced and total form, oxidative stress indices as malondialdehyde and allantoin/uric acid ratio were evaluated. LDL thiolation decreased in all treated patients, but a greater efficacy was attained from a combined therapy with a higher simvastatin dose, by which a 31% decrease of all S-bound thiols was reached after 1 year of therapy. In particular, in this patients group the reduction of apoB-Hcy was greater than 40%. The concomitant decrease of the oxidative stress indices during the therapy brings to the hypothesis that decreased levels of protein bound thiols may be a consequence of oxidative stress improvement. Therefore lipid lowering therapy may have beneficial effects also through the reduction of LDL-S-homocysteinylation that has been reported to have antiangiogenic and proatherogenic effect on endothelial vascular cells.

Item Type:Article
ID Code:7763
Status:Published
Refereed:Yes
Uncontrolled Keywords:Chronic kidney disease, homocysteine, LDL, homocysteinylation, LDL-S-Hcy
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier Science
ISSN:0928-0987
Deposited On:11 Jul 2012 13:19

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page