Bellia, Chiara and Tomaiuolo, Rossella and Caruso, Antonietta and Lo Sasso, Bruna and Zarrilli, Federica and Carru, Ciriaco and Deiana, Maria and Zinellu, Angelo and Pinna, Sara and Castaldo, Giuseppe and Deiana, Luca and Ciaccio, Marcello (2012) Fetuin-A serum levels are not correlated to kidney function in long-lived subjects. Clinical Biochemistry, Vol. 45 (9), p. 637-640. ISSN 0009-9120. eISSN 1873-2933. Article.
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Objectives: Serum Fetuin A has been identified as an inhibitor of ectopic calcification. It is reduced in subjects with chronic kidney disease (CKD) and it has been proposed as a potential link between CKD and the higher
prevalence of arterial calcification observed in these patients. During aging both the stiffening of arterial wall
due to calcification and a decline in kidney function are frequent. The aim of the study is to investigate if Fetuin
A serum levels are associated with aging and with AHSG T256S polymorphism. Moreover, we aim at investigate
whether serum Fetuin A is correlated to kidney function in this setting of senescence.
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