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Isolamento e caratterizzazione del genoma di un nuovo papillomavirus associato a carcinoma squamocellulare nella pecora sarda

Pintore, Francesca and Chessa, Bernardo and Pittau, Marco and Corradduzza, Elisabetta and Carcangiu, Laura and Addis, Maria Filippa and Cacciotto, Carla and Lecis, Roberta and Antuofermo, Elisabetta and Pirino, Salvatore and Alberti, Alberto (2008) Isolamento e caratterizzazione del genoma di un nuovo papillomavirus associato a carcinoma squamocellulare nella pecora sarda. In: 10. Congresso Nazionale S.I.Di.L.V., 22-24 Ottobre 2008, Alghero, Italy. [S.l.], [s.n.]. p. 266-267. Conference or Workshop Item.

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Abstract

This work describe the identification of a new papillomavirus strain (OvPV-3), associated to squamous cell carcinoma in sheep. The entire genome of OvPV-3 has been amplified by rolling circle amplification, characterized through restriction analysis, and cloned into pUC19. Partial sequencing revealed the presence of at least 5 orfs, two of them encoding for the known oncogenes E6 and E7. This is the first ovine papillomavirus isolated from squamous cell carcinoma. The virus is more similar to Alphapapillomavirus than to Deltapapillomavirus, even if it lacks a E5 orf.

Item Type:Conference or Workshop Item (Poster)
ID Code:7753
Status:Published
Uncontrolled Keywords:Virus oncogeni, rolling circle amplification, genome sequencing
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/05 Malattie infettive degli animali domestici
Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:001 Università di Sassari > 01 Dipartimenti > Patologia e clinica veterinaria
Publisher:[s.n.]
Deposited On:09 Jul 2012 13:15

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