Gadau, Sergio Domenico and Lepore, Gianluca and Zedda, Marco and Mura, Arcadia and Farina, Vittorio (2009) Different nitrosative-induced microtubular modifications and testosterone neuroprotective effects on high-D-glucose-exposed neuroblastoma and glioma cells. Neuroendocrinology Letters, Vol. 30 (4), p. 515-524. ISSN 0172-780X. Article.
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OBJECTIVES: Diabetic complications can often affect the central nervous system since the chronic exposure to hyperglycemia can result in the production of high concentration of reactive oxygen species with subsequent damage of several cell structures such as the cytoskeleton. In order to antagonize the oxidative status many substances have been tested as antioxidants. In the present work attention has been focused on the possible nitrosative effect of hyperglycemia on microtubular network of neuroblastoma and glioma mortalized cell lines, testing the possible neuroprotective effect of testosterone.
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