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Androgen receptor immunoreactivity in rat occipital cortex after callosotomy

Lepore, Gianluca and Gadau, Sergio Domenico and Mura, Arcadia and Arru, B. and Mulliri, G. and Zedda, Marco and Farina, Vittorio (2008) Androgen receptor immunoreactivity in rat occipital cortex after callosotomy. European Journal of Histochemistry, Vol. 52 (3), p. 163-168. eISSN 2038-8306. Article.

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Gonadal steroidogenesis can be influenced by direct neural links between the central nervous system and the gonads. It is known that androgen receptor (AR) is expressed in many areas of the rat brain involved in neuroendocrine control of reproduction,such as the cerebral cortex.It has been recently shown that the occipital cortex exerts an inhibitory effect on testicular stereoidogenesis by a pituitary-independent neural mechanism. Moreover, the complete transection of the corpus callosum leads to an increase in testosterone (T) secretion of hemigonadectomized rats. The present study was undertaken to analyze the possible corticocortical influences regulating male reproductive activities. Adult male Wistar rats were divided into 4 groups: 1) intact animals as control; 2) rats undergoing sham callosotomy; 3) posterior callosotomy; 4) gonadectomy and posterior callosotomy. Western blot analysis showed no remarkable variations in cortical AR expression in any of the groups except in group I where a significant decrease in AR levels was found. Similarly, both immunocytochemical study and cell count estimation showed a lower AR immunoreactivity in occipital cortex of callosotomized rats than in other groups. In addition, there was no difference in serum T and LH concentration between sham-callosotomized and callosotomized rats. In conclusion, our results showthat posterior callosotomy led to a reduction in AR in the right occipital cortex suggesting a putative inhibiting effect of the contralateral cortical area.

Item Type:Article
ID Code:7741
Uncontrolled Keywords:Androgen receptor, callosotomy, rat
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/01 Anatomia degli animali domestici
Divisions:001 Università di Sassari > 01 Dipartimenti > Biologia animale
Deposited On:05 Jul 2012 09:14

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