Capobianco, Giampiero and Donolo, Ermes and Borghero, Gianna and Dessole, Francesco and Cherchi, Pier Luigi and Dessole, Salvatore (2012) Effects of intravaginal estriol and pelvic floor rehabilitation on urogenital aging in postmenopausal women. Archives of Gynecology and Obstetrics, Vol. 285 (2), p. 397-403. eISSN 1432-0711. Article.
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Purpose To assess the effects of the combination of
pelvic floor rehabilitation and intravaginal estriol administration on stress urinary incontinence (SUI), urogenital atrophy and recurrent urinary tract infections in postmenopausal women.
Methods Two-hundred-six postmenopausal women with
urogenital aging symptoms were enrolled in this prospective
randomized controlled study. Patients were randomly
divided into two groups and each group consisted of 103
women. Subjects in the treatment group received intravaginal
estriol ovules, such as 1 ovule (1 mg) once daily for
2 weeks and then 2 ovules once weekly for a total of
6 months as maintenance therapy plus pelvic floor rehabilitation. Subjects in the control group received only
intravaginal estriol in a similar regimen. We evaluated
urogenital symptomatology, urine cultures, colposcopic
findings, urethral cytologic findings, urethral pressure
profiles and urethrocystometry before, as well as after
6 months of treatment.
Results After therapy, the symptoms and signs of urogenital atrophy significantly improved in both groups.
61/83 (73.49%) of the treated patients, and only 10/103
(9.71%) of the control patients referred a subjective
improvement of their incontinence. In the patients treated
by combination therapy with estriol plus pelvic floor
rehabilitation, we observed significant improvements of
colposcopic findings, and there were statistically significant increases in mean maximum urethral pressure (MUP), in mean urethral closure pressure (MUCP), as well as in the abdominal pressure transmission ratio to the proximal
Conclusions Our results showed that combination therapy with estriol plus pelvic floor rehabilitation was effective and should be considered as a first-line treatment for symptoms of urogenital aging in postmenopausal women.
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