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Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in mice

Farooqui, Amber and Leon, Alberto J. and Lei, Yanchang and Wang, Pusheng and Huang, Jianyun and Tenorio, Raquel and Dong, Wei and Rubino, Salvatore and Lin, Jie and Li, Guishuang and Zhao, Zhen and Kelvin, David J. (2012) Heterogeneous virulence of pandemic 2009 influenza H1N1 virus in mice. Virology Journal, Vol. 9 (104), p. 12. ISSN 1743-422X. Article.

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DOI: 10.1186/1743-422X-9-104

Abstract

Background
Understanding the pathogenesis of influenza infection is a key factor leading to the prevention and control of future outbreaks. Pandemic 2009 Influenza H1N1 infection, although frequently mild, led to a severe and fatal form of disease in certain cases that make its virulence nature debatable. Much effort has been made toward explaining the determinants of disease severity; however, no absolute reason has been established.
Results
This study presents the heterogeneous virulence of clinically similar strains of pandemic 2009 influenza virus in human alveolar adenocarcinoma cells and mice. The viruses were obtained from patients who were admitted in a local hospital in China with a similar course of infection and recovered. The A/Nanchang/8002/2009 and /Nanchang/8011/2009 viruses showed efficient replication and high lethality in mice while infection with A/Nanchang/8008/2009 was not lethal with impaired viral replication, minimal pathology and modest proinflammatory activity in lungs. Sequence analysis displayed prominent differences between polymerase subunits (PB2 and PA) of viral genomes that might correlate with their different phenotypic behavior.
Conclusions
The study confirms that biological heterogeneity, linked with the extent of viral replication, exists among pandemic H1N1 strains that may serve as a benchmark for future investigations on influenza pathogenesis.

Item Type:Article
ID Code:7693
Status:Published
Refereed:Yes
Uncontrolled Keywords:Pandemic H1N1 influenza, viral heterogeneity, clinical presentation, host adaptation, viral polymerase, virulence, pathogenesis
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:BioMed Central Ltd.
ISSN:1743-422X
Copyright Holders:© 2012 Farooqui et al. ; licensee BioMed Central Ltd.
Deposited On:12 Jun 2012 12:02

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