Abstract

Kaposi’s sarcoma (KS) is a multicentric vascular neoplasia characterized by macules, nodules and angiomatoid plaques mainly present on the skin surface. Four KS variants are recognized: classic or Mediterranean; endemic or African; the variant following on renal transplant or immunosuppressive therapy; and, lastly, the epidemic or AIDS-associated variant. The variants differ in the sites involved, course of the disease and in their prognosis. Genetic, immunological, environmental and viral factors have proven to be relevant in the aetiology and pathogenesis of all KS variants. In addition, further possible interacting factors such as mycoplasma infections have come to attention for the single variants.

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