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New V. cholerae atypical El Tor variant emerged during the 2006 epidemic outbreak in Angola

Ceccarelli, Daniela and Spagnoletti, Matteo and Bacciu, Donatella and Cappuccinelli, Pietro Antonio and Colombo, Mauro Maria (2011) New V. cholerae atypical El Tor variant emerged during the 2006 epidemic outbreak in Angola. BMC Microbiology, Vol. 11 (130), p. 1-8. eISSN 1471-2180. Article.

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DOI: 10.1186/1471-2180-11-130

Abstract

Background
V. cholerae is the etiological agent of cholera, a major public health concern in most developing countries. Virulence of V. cholerae relies on the powerful cholera toxin, encoded by the CTX prophage. The emergence of new pathogenic variants in the recent years has been mostly associated with new CTX prophage rearrangements.
Results
In this retrospective study, we show that the epidemic V. cholerae O1 El Tor strain responsible for the 2006 outbreak in Angola is clonally and genetically different from El Tor strains circulating in the 1990s in the same area. Strains from 2006 carry ICEVchAng3 of the SXT/R391 family. This ICE is associated with a narrower multidrug resistance profile compared to the one conferred by plasmid p3iANG to strains of the 1990s. The CTX prophage carried by 2006 El Tor strains is characterized by rstRET and ctxBCla alleles organized in a RS1-RS2-Core array on chromosome I. Interestingly, the newly emerging atypical strain belongs to a clade previously known to comprise only clinical isolates from the Indian subcontinent that also contain the same ICE of the SXT/R391 family.
Conclusions
Our findings remark the appearance of a novel V. cholerae epidemic variant in Africa with a new CTXΦ arrangement previously described only in the Indian Subcontinent.

Item Type:Article
ID Code:7617
Status:Published
Refereed:Yes
Uncontrolled Keywords:Vibrio cholerae, El Tor strain, Angola
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:BioMed Central
eISSN:1471-2180
Copyright Holders:© 2011 Ceccarelli et al; licensee BioMed Central Ltd.
Deposited On:24 May 2012 10:56

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