Spivey, Tara L. and Uccellini, Lorenzo and Ascierto, Maria Libera and Zoppoli, Gabriele and De Giorgi, Valeria and Delogu, Lucia Gemma and Engle, Alyson M. and Thomas, Jaime M. and Wang, Ena and Marincola, Francesco M. and Bedognetti, Davide (2011) Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis. Journal of Translational Medicine, Vol. 9 (174), p. 1-22. eISSN 1479-5876. Article.
In humans, the role and relationship between molecular pathways that lead to tissue destruction during acute allograft rejection are not fully understood. Based on studies conducted in humans, we recently hypothesized that different immune-mediated tissue destruction processes (i.e. cancer, infection, autoimmunity) share common convergent final mechanisms. We called this phenomenon the "Immunologic Constant of Rejection (ICR)." The elements of the ICR include molecular pathways that are consistently described through different immune-mediated tissue destruction processes and demonstrate the activation of interferon-stimulated genes (ISGs), the recruitment of cytotoxic immune cells (primarily through CXCR3/CCR5 ligand pathways), and the activation of immune effector function genes (IEF genes; granzymes A/B, perforin, etc.).
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