Pizzocri, Jessica Isabella (2008) Efficacia dell'agente cetilpiridinio cloruro sui microrganismi orali cariogeni e putrefattivi: studio in vivo sulla prevenzione della carie dentale e dell'alitosi di origine orale. Doctoral Thesis.
The aim of this study was to evaluate the effect of a 0.1% cetylpyridinium chloride mouthwash on salivary concentration of Streptococcus mutans and halitosis microrganism; this mouthwash was contained in jelly microcapsule. Cetylpyridinium chloride is a quaternary ammonium compound, with an aliphatic chain with positive cationic surface; it shows an antiseptic and bactericidal activity on gram-positive microrganisms. The sample was 20-40-year-old and was hight risk of caries (S. mutans > 10^5 CFU/ml). Were excluded to sample subject with systemic pathology, under farmacology treatments or under topical and systemic treatment with chlorexidine and fluoride compounds in the period of the study or for 30 days. A written consensus was request to all participants to study. The protocol was based on giving 2/4/6 pearls with 0,1% CPC or placebo for 3 days to all partecipants; samples of saliva were collected after 1, 5, 10, 60 minutes. In the first day was collected a sample of biofilm from tongue’s back basal portion with a sterile plug. This sample was analized with “Bana Test”. Conclusions: 0,1% cetylpyridinium chloride’s use implies SM salivary concentration decrease. This decrease is temporary, so pearls may be considered a method only for regulate SM salivary concentration, but not either for avert dental caries or oral halitosis.
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