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NF-κB as potential target in the treatment of melanoma

Madonna, Gabriele and Ullman, Claudio Dansky and Gentilcore, Giusy and Palmieri, Giuseppe and Ascierto, Paolo Antonio (2012) NF-κB as potential target in the treatment of melanoma. Journal of Translational Medicine, Vol. 10 (53). eISSN 1479-5876. Article.

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DOI: 10.1186/1479-5876-10-53


The RAS/MAP kinase pathway has attracted attention because activating mutations of the BRAF serine/threonine kinase was described in over 50% of melanomas. Very recently, selective and potent BRAF inhibitors have been developed. Several other signal transduction pathways have been found to be constitutively active or mutated in other subsets of melanoma tumors that are potentially targetable with new agents. Among these, NFκB is another pathway that melanoma tumors use to achieve survival, proliferation and resistance to apoptosis. Inhibition of NF-κB activation appears to be a very promising option for anti-cancer therapies.

Item Type:Article
ID Code:7578
Uncontrolled Keywords:NF-κB, melanoma, NBD peptide, bortezomib, curcumin
Subjects:Area 06 - Scienze mediche > MED/06 Oncologia medica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
Publisher:BioMed Central
Copyright Holders:© 2012 Madonna et al; licensee BioMed Central Ltd.
Deposited On:23 May 2012 11:05

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