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Dye release behavior from polyvinyl alcohol films in a hydro-alcoholic medium: influence of physicochemical heterogeneity

Cozzolino, Carlo Alessio and Blomfeldt, Thomas O.J. and Nilsson, Fritjof and Piga, Antonio <1965- > and Piergiovanni, Luciano and Farris, Stefano (2012) Dye release behavior from polyvinyl alcohol films in a hydro-alcoholic medium: influence of physicochemical heterogeneity. Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 403 , p. 45-53. eISSN 1873-4359. Article.

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DOI: 10.1016/j.colsurfa.2012.03.054


In this paper we investigated the release kinetics of a model drug-like compound (Coomassie brilliant blue) from polyvinylalcohol (PVOH) films into ahydro-alcoholic solution as a function of the physicochemical properties of the polymer matrix. After 33 days of monitoring, the total amount released ranged from 10% for the high hydrolysis degree/low molecular weight PVOH films to 60% for the low hydrolysis degree/low molecular weight films. Mathematical modeling allowed for an estimation of the two diffusion coefficients (D1 and D2) that characterized the release profile of the dye from the films. The degree of hydrolysis dramatically affected both the morphology and the physical structure of the polymer network. A high hydroxyl group content was also associated with the shifting of second order and first order transitions toward higher temperatures, with a concurrent increase in crystallinity. Moreover, the higher the degree of hydrolysis, the higher the affinity of the polymer to the negatively charged molecule dye. Selection of the polymer matrix based on physicochemical criteria may help in achieving different release patterns, thereby representing the first step for the production of polymer systems with modulated release properties.

Item Type:Article
ID Code:7574
Uncontrolled Keywords:Controlled release, diffusion, modeling, morphology, polyvinyl alcohol
Subjects:Area 07 - Scienze agrarie e veterinarie > AGR/15 Scienze e tecnologie alimentari
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Agraria
Deposited On:17 May 2012 11:29

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