Colasanti, Tania and Maselli, Angela and Conti, Fabrizio and Sanchez, Massimo and Alessandri, Cristiano and Barbati, Cristiana and Vacirca, Davide and Tinari, Antonella and Chiarotti, Flavia and Giovannetti, Antonello and Franconi, Flavia and Valesini, Guido and Malorni, Walter and Pierdominici, Marina and Ortona, Elena (2012) Autoantibodies to estrogen receptor α interfere with T lymphocyte homeostasis and are associated with disease activity in systemic Lupus erythematosus. Arthritis & Rheumatism, Vol. 64 (3), p. 778-787. eISSN 1529-0131. Article.
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Objective. Estrogens influence many physiologic
processes and are also implicated in the development or
progression of numerous diseases, including autoimmune
disorders. Aberrations of lymphocyte homeostasis
that lead to the production of multiple pathogenic
autoantibodies, including autoantibodies specific to estrogen receptor (ER), have been detected in the peripheral
blood of patients with systemic lupus erythematosus
(SLE). This study was undertaken to assess the
presence of both anti-ERα and anti-ERβ antibodies in
sera from patients with SLE, to analyze the effect of
these antibodies on peripheral blood T lymphocyte
homeostasis, and to evaluate their role as determinants
of disease pathogenesis and progression.
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