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Are T-cell dysfunctions the other side of the moon in the pathogenesis of myelodysplastic syndromes?

Fozza, Claudio and Longinotti, Maurizio Roberto (2012) Are T-cell dysfunctions the other side of the moon in the pathogenesis of myelodysplastic syndromes? European Journal of Haematology, Vol. 88 (5), p. 380-387. eISSN 1600-0609. Article.

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DOI: 10.1111/j.1600-0609.2012.01762.x

Abstract

Even though the pathogenesis of myelodysplastic syndromes (MDS) is dominated by an inefficient maturation of haematopoietic precursors, also immune mechanisms seem to play a crucial functional role. In this review, we will first describe the clinical and laboratory autoimmune manifestations often detectable in MDS patients. We will then focus on studies addressing the mechanisms of T-cell activation and their implications in the disease history. The potential impact of specific cell subsets, such as regulatory T-cells, Th17 cells and natural killer cells, will be also described. We will finally focus on potential therapeutic approaches based on immunomodulation, ranging from more classical immunosuppressive drugs to vaccination and transplantation strategies.

Item Type:Article
ID Code:7551
Status:Published
Refereed:Yes
Uncontrolled Keywords:Myelodysplastic syndromes, autoimmunity, T-cells, immunomodulating therapies
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 03 Istituti > Ematologia
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Blackwell / Wiley
eISSN:1600-0609
Deposited On:10 May 2012 16:07

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