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Development of new topical formulations of diphenhydramine hydrochloride: in vitro diffusion and in vivo preliminary studies

Sanna, Vanna Annunziata and Peana, Alessandra Tiziana and Moretti, Mario Domenico Luigi (2010) Development of new topical formulations of diphenhydramine hydrochloride: in vitro diffusion and in vivo preliminary studies. International Journal of PharmTech Research, Vol. 2 (1), p. 863-869. ISSN 0974-4304. Article.

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Abstract

The aim of this study was to evaluate the vehicle effect on in vitro diffusion of Diphenhydramine hydrochloride (DPH) from new five topical formulations: microemulsion (A), microemulsion+silica (B), Na Alginate emulgel (C), Carbopol cream (D) and hydroxyethylcellulose gel (E).Furthermore, the skin irritation potential and the formulation effect on skin reaction induced by histamine were investigated in vivo. The commercial cream of DPH (Allergan®) was used as reference formulation.The diffusion rate values showed the rank order E > A > B > C > D > Control, and all prepared formulations are able to improve the diffusion of drug compared with commercial cream; among the tested formulations, the hydroxyethylcellulose gel and microemulsions appear to be the most efficient vehicles in promoting the release of DPH.After in vivo application, the formulations do not produce skin irritation and determine a reduction of the response induced by histamine suggesting that their potential use as alternative topical dosage forms for effective local antihistaminic therapy.

Item Type:Article
ID Code:7451
Status:Published
Refereed:Yes
Uncontrolled Keywords:Diphenhydramine hydrochloride, diffusion studies, skin test
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Porto Conte Ricerche, Alghero
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Sphinx Knowledge House
ISSN:0974-4304
Deposited On:30 Apr 2012 12:31

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