titoli, abstracts, parole chiave >>>
Plasma mutant-p53 protein and anti-p53 antibody as a marker: an experience in vinyl chloride workers in Italy

Mocci, Francesco and Nettuno, Marina (2006) Plasma mutant-p53 protein and anti-p53 antibody as a marker: an experience in vinyl chloride workers in Italy. Journal of occupational and environmental medicine, Vol. 48 (2), p. 158-164. eISSN 1536-5948. Article.

Full text not available from this repository.

Alternative URLs:

Abstract

OBJECTIVE: The objective of this study was to examine the presence of mutant-p53 protein (p53Ag) and antibodies to p53 protein (p53Ab) in a population of workers exposed to vinyl chloride (VC).
METHOD: We have investigated the presence of two cancer markers in the plasma of 151 subjects exposed to varying concentrations of VC (4-2823 ppm). The investigation took place in two sessions: in 1999, the analysis was limited to p53Ab, and in 2000, the analysis was repeated and extended to include also the mutant-p53Ag. The available information on the subjects in this study includes age, total years of employment in the VC polymerization industry, exposure concentration, results of abdominal ultrasonogram, hepatitis status, smoking and alcohol drinking status, and clinical records. Logistic regression analyses were performed to calculate the association between prevalence of positivity for p53Ab or mutant-p53Ag and cumulative VC exposure concentration after adjustment for confounding factors. t test and chi analyses were performed to test significant differences among groups.
RESULTS: Three (1.9%) of the 151 workers exposed to VC resulted seropositive for the mutant-p53Ag and five (3.3%) for the p53Ab. All seropositive subjects are distributed in the highest exposure classes (>1000 ppm). No seropositivity was found among controls. The stratified relationship between seropositivity and exposure appeared statistically significant (chi = 23.65 for mutant-p53Ag and 30.35 for p53Ab).
CONCLUSIONS: revealing its presence in subjects having a history of VC exposure greater than 1000 ppm. On the basis of this study, and the clinical experience of the authors, the presence of a minimum threshold for the carcinogenic effects of VC is hypothesized.

Item Type:Article
ID Code:7445
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mutant-p53 protein (p53Ag), antibodies to p53 protein (p53Ab), vinyl chloride (VC)
Subjects:Area 06 - Scienze mediche > MED/44 Medicina del lavoro
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Lippincott Williams & Wilkins
eISSN:1536-5948
Deposited On:30 Apr 2012 10:54

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page