UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Verapamil prevents the acute hypertensive response to intracerebroventricular cadmium in conscious normotensive rats

Madeddu, Paolo Roberto and Demontis, Maria Piera and Varoni, Maria Vittoria and Fattaccio, Maria Caterina and Palmieri, Alessandra and Anania, Vittorio Domenico (1993) Verapamil prevents the acute hypertensive response to intracerebroventricular cadmium in conscious normotensive rats. American Journal of Hypertension, Vol. 6 (3), p. 193-197. ISSN 0895-7061. Article.

Full text not available from this repository.

Alternative URLs:

Abstract

Cadmium, a trace element from natural and industrial sources, may contribute to the pathogenesis of arterial hypertension. We evaluated the effect induced by acute intracerebroventricular (icv) administration of cadmium on mean blood pressure of normotensive conscious rats. Intracerebroventricular cadmium (1 to 10 micrograms) produced a dose-dependent, sustained increase in mean blood pressure. The hypertensive response to icv cadmium was significantly (P < .01) prevented by icv pretreatment with verapamil (10 to 100 micrograms). A preventive effect was exerted also by icv nifedipine (100 micrograms); however, this result was attributable, at least in part, to the antihypertensive action of the vehicle, polyethylene glycol. The hypertensive response to icv cadmium was blunted by icv administration of 10 ng clonidine, 10 micrograms vasopressin antagonist, or 10 micrograms bradykinin antagonist (P < .05), but it was not altered by icv enalaprilat (100 micrograms). These results indicate that brain calcium channels play a role in the hypertensive action induced by icv cadmium. Accumulation of cadmium in the brain caused by prolonged exposure to this heavy metal might lead to chronic arterial hypertension.

Item Type:Article
ID Code:7379
Status:Published
Refereed:Yes
Uncontrolled Keywords:Verapamil, Cadmium, acute intracerebroventricular (icv) administration, hypertensive response
Subjects:Area 06 - Scienze mediche > MED/42 Igiene generale e applicata
Area 07 - Scienze agrarie e veterinarie > VET/07 Farmacologia e tossicologia veterinaria
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Biologia animale
Publisher:Elsevier Science / Nature Publishing Group
ISSN:0895-7061
Deposited On:13 Apr 2012 12:21

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page