Álvarez, Pablo J. and Marchal Corrales, Juan Antonio and Boulaiz, Houria and Carrillo Delgado, Esmeralda Esperanza and Vélez, Celia and Rodríguez-Serrano, Fernando and Melguizo, Consolación and Prados Salazar, José Carlos and Madeddu, Roberto Beniamino and Aranega Jiménez, Antonia (2012) 5-Fluorouracil derivatives: a patent review. Expert Opinion on Therapeutic Patents, Vol. 22 (2), p. 107-123. eISSN 1744-7674. Article.
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Introduction: The fluorinated analog of uracil 5-FU is an antimetabolite, active against a wide range of solid tumors. The main mechanism of action consists in interfering with DNA synthesis and mRNA translation. However, patients treated with 5-FU display several side effects, a result of its nonspecific cytotoxicity for tumor cells. Numerous modifications of the 5-FU structure have been performed in order to overcome these disadvantages.
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