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Ex vivo impact of functionalized carbon nanotubes on human immune cells

Delogu, Lucia Gemma and Venturelli, Enrica and Manetti, Roberto and Pinna, Gérard Aimé and Carru, Ciriaco and Madeddu, Roberto Beniamino and Murgia, Luciano and Sgarrella, Francesco and Dumortier, Hélène and Bianco, Alberto (2012) Ex vivoimpact of functionalized carbon nanotubes on human immune cells. Nanomedicine, Vol. 7 (2), p. 231-243. eISSN 1748-6963. Article.

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DOI: 10.2217/nnm.11.101

Abstract

Aim: Different studies, carried out by us and others, have investigated the impact of carbon nanotubes (CNTs) in vitro and in animal models. To date, only a few studies have been performed on human cells ex vivo. There is also a lack of comparison between CNTs with varied functionalization and structural properties and their impact on different cell types. Materials & Methods: The present ex vivo human study focuses on the impact of a series of functionalized multiwalled CNTs on human T and B lymphocytes, natural killer (NK) cells and monocytes. Results: Smaller diameter nanotubes are internalized more efficiently. Viability assays displayed the absence of cytotoxicity of all multiwalled CNTs used. Activation assay demonstrated a strong effect on monocytes and NK cells. Conclusion: Our results, on human cells ex vivo, confirmed previous studies demonstrating appropriately functionalized CNTs are nontoxic. The effects on cell functionality were significant for the monocytes and NK cells. These findings encourage the possible use of CNTs for biomedical applications either as carriers of therapeutic molecules or as immune modulator systems.

Item Type:Article
ID Code:7330
Status:Published
Refereed:Yes
Uncontrolled Keywords:Nanotubes, immune cells
Subjects:Area 05 - Scienze biologiche > BIO/17 Istologia
Area 05 - Scienze biologiche > BIO/10 Biochimica
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Future Medicine
eISSN:1748-6963
Deposited On:05 Apr 2012 08:49

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