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Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients

Malaguarnera, Lucia and Madeddu, Roberto Beniamino and Palio, Elisabetta and Malaguarnera, Mariano and Arena, Nicolò (2005) Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients. Journal of Hepatology, Vol. 42 (4), p. 585-591. eISSN 1600-0641. Article.

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DOI: 10.1016/j.jhep.2004.11.040

Abstract

Background/Aims Non-alcoholic steatohepatitis (NASH) is a disorder that is histologically characterized by macrovesicular steatosis and lobular hepatitis with necrosis or ballooning degeneration and fibrosis. NASH can range from a benign condition to end-stage liver disease. The mechanisms promoting transition from steatosis to NASH appear to involve multiple cellular adaptations to the oxidative stress occurring when fatty acid metabolism is altered. We evaluated the relationship between lipid peroxidation and other oxidative stress biomarkers with changes in expression of heme oxygenase-1 (HO-1) in human hepatic steatosis ranging from simple steatosis to NASH.
Methods HO-1 expression, lipid peroxidation, ferritin and GSH levels were assayed from liver biopsies obtained from 60 subjects: 35 with NASH, 15 with simple steatosis and 10 controls.
Results The HO-1 expression was significantly increased in NASH patients and the increase reflected the severity of the disease. A significant correlation was observed between the increased levels of HO-1 and ferritin, and between the increased levels of HO-1 and lipid peroxidation. Moreover, NASH patients with lower levels of GSH exhibited higher expression of HO-1.
Conclusions The induction of HO-1 is an adaptive response against oxidative damage elicited by lipid peroxidation and it may be critical in the progression of the disease.

Item Type:Article
ID Code:7282
Status:Published
Refereed:Yes
Uncontrolled Keywords:Non-alcoholic steatohepatitis, simple steatosis, Heme oxygenase-1, Ferritin, lipid peroxidation, GSH
Subjects:Area 05 - Scienze biologiche > BIO/17 Istologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Elsevier
eISSN:1600-0641
Copyright Holders:© 2005 European Association for the Study of the Liver
Deposited On:22 Mar 2012 14:14

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