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Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis

Madeddu, Roberto Beniamino and Farace, Cristiano and Tolu, Paola and Solinas, Maria Giuliana and Asara, Yolande and Sotgiu, Maria Alessandra and Delogu, Lucia Gemma and Prados Salazar, José Carlos and Sotgiu, Stefano and Montella, Andrea Costantino Mario (2013) Cytoskeletal proteins in the cerebrospinal fluid as biomarker of multiple sclerosis. Neurological sciences, Vol. 34 (2), p. 181-186. eISSN 1590-3478. Article.

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DOI: 10.1007/s10072-012-0974-4

Abstract

The axonal cytoskeleton is a finely organized system, essential for maintaining the integrity of the axon. Axonal degeneration is implicated in the pathogenesis of unremitting disability of multiple sclerosis (MS). Purpose of this study is to evaluate levels of cytoskeletal proteins such as neurofilament light protein (NFL), glial fibrillary acidic protein (GFAP), and β-tubulin (β-Tub) isoforms II and III in the cerebrospinal fluid (CSF) of MS patients and their correlation with MS clinical indices. CSF levels of cytoskeletal proteins were determined in 51 patients: 33 with MS and 18 with other neurological diseases (OND). NFL, GFAP and β-Tub II proteins were significantly higher (p<0.0001) in MS than in OND group; no significant difference (p>0.05) was found between MS and OND with regard to β-Tub III. Interestingly, levels of b-Tub III and NFL were higher in progressive than in remitting MS forms; on the contrary, higher levels of β-Tub II and GFAP were found in remitting MS forms. However, with the exception of β-Tub III, all proteins tend to decrease their CSF levels concomitantly with the increasing disability (EDSS) score. Overall, our results might indicate β-Tub II as a potential candidate for diagnostic and β-Tub III as a possible prognostic biomarker of MS. Therefore, further analyses are legitimated and desirable.

Item Type:Article
ID Code:7228
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, biomarkers, cerebrospinal fluid, cytoskeletal proteins, axonal damage
Subjects:Area 05 - Scienze biologiche > BIO/17 Istologia
Area 06 - Scienze mediche > MED/39 Neuropsichiatria infantile
Area 06 - Scienze mediche > MED/01 Statistica medica
Area 05 - Scienze biologiche > BIO/16 Anatomia umana
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Springer
eISSN:1590-3478
Copyright Holders:© Springer-Verlag 2012
Deposited On:19 Mar 2012 08:57

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