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Interaction between Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium subspecies paratuberculosis with the enteric glia and microglial cells

Cannas, Sara and Molicotti, Paola and Bua, Alessandra and Usai, Donatella and Sechi, Leonardo Antonio and Scanu, Antonio Mario and Blasi, Elisabetta and Zanetti, Stefania Anna Lucia (2011) Interaction between Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium avium subspecies paratuberculosis with the enteric glia and microglial cells. Gut Pathogens, Vol. 3 (19), p. 1-7. eISSN 1757-4749. Article.

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DOI: 10.1186/1757-4749-3-19

Abstract

Background
We investigated the interaction of Mycobacterium avium subspecies paratuberculosis, M. bovis and M. tuberculosis and different glial cells (enteric glial and microglial cells) in order to evaluate the infecting ability of these microorganisms and the effects produced on these cells, such as the evaluation of cytokines expression.
Results
Our experiments demonstrated the adhesion of M. paratuberculosis to the enteroglial cells and the induction of IL-1A and IL-6 expression; M. tuberculosis and M. bovis showed a good adhesive capability to the enteric cell line with the expression of the following cytokines: IL-1A and IL-1B, TNF-α, G-CSF and GM-CSF; M. bovis induced the expression of IL-6 too.
The experiment performed with the microglial cells confirmed the results obtained with the enteroglial cells after the infection with M. tuberculosis and M. bovis, whereas M. paratuberculosis stimulated the production of IL-1A and IL-1B.
Conclusion
Enteroglial and microglial cells, could be the target of pathogenic mycobacteria and, even if present in different locations (Enteric Nervous System and Central Nervous System), show to have similar mechanism of immunomodulation.

Item Type:Article
ID Code:7210
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mycobacteria, enteric glial cells, microglia, cytokines
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 06 - Scienze mediche > MED/18 Chirurgia generale
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 01 Dipartimenti > Medicina clinica, sperimentale e oncologica
Publisher:BioMed Central
eISSN:1757-4749
Copyright Holders:© 2011 Cannas et al; licensee BioMed Central Ltd
Deposited On:13 Mar 2012 11:38

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