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Composition and in vitro antimicrobial activity of the essential oil of Thymus herba-barona Loisel growing wild in Sardinia

Juliano, Claudia Clelia Assunta and Mattana, Antonella and Usai, Marianna (2000) Composition and in vitro antimicrobial activity of the essential oil of Thymus herba-barona Loisel growing wild in Sardinia. Journal of Essential Oil Research, Vol. 12 (4), p. 516-522. ISSN 1041-2905 . Article.

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Two samples of the essential oils from Thymus herba-barona Loisel (Labiatae) of Sardinian origin were chemically characterized and their antimicrobial activity evaluated, in comparison with T. vulgaris and T. serpyllum oils, on the basis of their minimum inhibitory concentrations (M.I.C.s) and of the contact times required to totally inhibit development of microorganisms. GC and GC/MS analysis showed that the main components of essential oils of T. herba-barona were carvacrol (75.4% and 73–0%), borneol (3.6% and 6.4%) and p-cymene (3.9% and 3.3%), while the percentage of thymol was very low (1.0% and 0.7%). Results of the antimicrobial investigation demonstrated that both oils possessed similar and relevant microbicidal activities, especially against Gram+ bacteria (M.I.C.s range 0.125–0.500 mg/mL) and mycetes (M.I.C.s 0.125–0.500 mg/mL). At inhibitory concentrations, times required to kill microbial inocula (5–10 min) are comparable with those of chlorhexidine gluconate, an antiseptic with a broad range of antimicrobial activities. The strong activity of T. herba-barona oils is very probably due to the presence of carvacrol, which was found from our screenings to exhibit a similar antimicrobial activity. Our findings provide for a rationale basis of a possible utilization of this oil in fields requiring safe and cheap compounds with antiseptic and preservative properties, such as cosmetic, pharmaceutical and food industries.

Item Type:Article
ID Code:7154
Uncontrolled Keywords:Thymus herba-barona, Thymus vulgaris, Thymus serpyllum, Labiatae, essential oil composition, carvacrol, antimicrobial activity
Subjects:Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Area 05 - Scienze biologiche > BIO/15 Biologia farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Allured Publishing Corp.
Deposited On:24 Feb 2012 09:20

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