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Immunogenetic heterogeneity of multiple sclerosis in Sardinia

Sotgiu, Stefano and Pugliatti, Maura and Solinas, Maria Giuliana and Castiglia, Paolo Giuseppino and Sanna, Alessandra and Rosati, Giulio (2001) Immunogenetic heterogeneity of multiple sclerosis in Sardinia. Neurological sciences, Vol. 22 (2), p. 167-170. eISSN 1590-3478. Article.

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DOI: 10.1007/s100720170018

Abstract

Multiple sclerosis (MS) predisposition is thought to be influenced by a complex, yet unclear interaction of genetic and environmental factors. Studying ethnically selected populations may reduce genetic and environmental heterogeneities and help clarify the underlying mechanisms of MS susceptibility. Sardinians kept a homogeneous genetic structure and have among the highest MS frequency rates worldwide. Interestingly, MS in Sardinia is linked to otherwise rare HLA alleles. In this light, recent findings from epidemiological and immunogenetic studies of Sardinian MS are presented. Results confirm that, likely due to significant genetic differences at a microgeographic level, even in this homogeneous population MS is immunogenetically heterogeneous and tends to preferentially cluster in some more archaic areas of the island.

Item Type:Article
ID Code:7083
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, epidemiology, HLA, Sardinia
Subjects:Area 06 - Scienze mediche > MED/42 Igiene generale e applicata
Area 06 - Scienze mediche > MED/39 Neuropsichiatria infantile
Area 06 - Scienze mediche > MED/01 Statistica medica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Clinica neurologica
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
001 Università di Sassari > 03 Istituti > Igiene e medicina preventiva
Publisher:Springer
eISSN:1590-3478
Deposited On:09 Feb 2012 15:53

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