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Multiple sclerosis prevalence among Sardinians: further evidence against the latitude gradient theory

Pugliatti, Maura and Sotgiu, Stefano and Solinas, Maria Giuliana and Castiglia, Paolo Giuseppino and Rosati, Giulio (2001) Multiple sclerosis prevalence among Sardinians: further evidence against the latitude gradient theory. Neurological sciences, Vol. 22 (2), p. 163-165. eISSN 1590-3478. Article.

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DOI: 10.1007/s100720170017


A descriptive epidemiological survey was extended to the whole province of Sassari, northern Sardinia between latitudes 40°30' N and 41° N. Results showed a crude total prevalence rate of 144.4 per 100 000 on prevalence day (31 December 1997), and an onset-adjusted prevalence rate of 149.7 per 100 000. The total average annual incidence rate was 4.9 per 100 000 for the whole time interval studied (1968–1997), having increased from 2.0 in 1968–1972 to 6.8 in the last quinquennium considered. A substantial improvement in MS case ascertainment due to the introduction of new diagnostic procedures might account for such rates in Sardinia as well as in other Italian regions. However, when comparing our data with those obtained in the province of Ferrara, in the same time frames (1968–1997), a nine-fold versus a five-fold increase of MS prevalence was detected in Ferrara and Sassari, respectively. MS incidence temporal trend also notably increased in Sassari, but remained substantially stable in Ferrara. The progressive shortening of the time interval between clinical onset and diagnosis, and the proportion of benign-mild MS cases, were similar diagnostic accuracy. In our opinion, the repeatedly assessed increase of MS frequency in our province, at least partially does represent an actual rise of MS risk among Sardinians, thus disproving the latitude gradient-based theory (i.e. prevalence rates correlate with geographical latitudes) and supporting the hypothesis of a “Sardinian focus” of MS in a genetically susceptible population.

Item Type:Article
ID Code:7082
Uncontrolled Keywords:Multiple sclerosis, prevalence, incidence, Sardinia
Subjects:Area 06 - Scienze mediche > MED/42 Igiene generale e applicata
Area 06 - Scienze mediche > MED/39 Neuropsichiatria infantile
Area 06 - Scienze mediche > MED/01 Statistica medica
Area 06 - Scienze mediche > MED/26 Neurologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Clinica neurologica
001 Università di Sassari > 01 Dipartimenti > Neuroscienze, scienze materno infantili
001 Università di Sassari > 03 Istituti > Igiene e medicina preventiva
Deposited On:09 Feb 2012 15:31

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