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An Ecologic study of geographical variation in multiple sclerosis risk in central Sardinia, Italy

Montomoli, Cristina and Allemani, C. and Solinas, Maria Giuliana and Motta, G. and Bernardinelli, Luisa and Clemente, Simonetta and Murgia, Bruno Salvatore and Ticca, Anna F. and Musu, Luigina and Piras, Maria Luisa and Ferrai, Raffaela and Caria, Antonella and Sanna, Stefania and Porcu, Orsola (2002) An Ecologic study of geographical variation in multiple sclerosis risk in central Sardinia, Italy. Neuroepidemiology, Vol. 21 (4), p. 187-193. eISSN 1423-0208. Article.

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DOI: 10.1159/000059522

Abstract

We carried out an ecological study in the most archaic area of Sardinia to obtain a reliable estimate of the prevalence of multiple sclerosis (MS) and to investigate the geographical variation in the prevalence across the 100 administrative communes. To estimate the area-specific prevalence rate, we adopted a Bayesian approach that makes it possible to filter out the random variation from the estimates and to obtain a map that reflects the true geographical variation in MS prevalence. 428 resident cases were identified by the case register, including 69 multiplex families. The overall prevalence was 157 per 100,000 inhabitants. The Bayesian area-specific prevalence ranged from 143 to 262/100,000. The high prevalence and its moderate geographical variation in a genetically homogeneous population, as well as the high number of multiplex families observed in the communes with the highest prevalence, could be interpreted as representing a high susceptibility of the population to MS.

Item Type:Article
ID Code:7073
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multiple sclerosis, epidemiology, Bayesian models, Sardinia
Subjects:Area 06 - Scienze mediche > MED/01 Statistica medica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL3, Nuoro > Centro di riabilitazione, Macomer
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL3, Nuoro > Ospedale "San Francesco"
Publisher:Karger
eISSN:1423-0208
Deposited On:09 Feb 2012 09:45

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