UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Six months of daily high-dose xylitol in high-risk schoolchildren: a randomized clinical trial on plaque pH and salivary mutans streptococci

Campus, Guglielmo Giuseppe and Cagetti, Maria Grazia and Sacco, Gianluca and Solinas, Maria Giuliana and Mastroberardino, Stefano and Lingström, Peter (2009) Six months of daily high-dose xylitol in high-risk schoolchildren: a randomized clinical trial on plaque pH and salivary mutans streptococci. Caries Research, Vol. 43 (6), p. 455-461. eISSN 1421-976X. Article.

Full text not available from this repository.

DOI: 10.1159/000264682

Abstract

A randomized clinical trial was designed to evaluate the effect of daily high-dose xylitol chewing gum on plaque pH and salivary mutans streptococci (MS) in a sample of schoolchildren at high risk of caries. The study was performed on 204 subjects (acceptance rate 88.3%). Inclusion criteria were: >1 and <4 carious lesions, and a salivary MS concentration >105 CFU/ml. Subjects were randomly assigned to the xylitol or control group. Study design included one examination at baseline (t0), one after 3 months of chewing (t1), one after 6 months of chewing (t2) and the last 3 months after the end of chewing period (t3). Plaque pH was assessed using the MicroTouch technique, following a sucrose challenge. The area under the curve (AUC5.7 and AUC6.2) was recorded. Whole saliva was collected in sterile vials and MS CFU/ml were counted. Data were analysed using repeated-measures ANOVA. The main result was that plaque acidogenicity was reduced in both groups. The differences between treatments were statistically significant both for plaque pH and MS concentration; the interaction term for treatment and time was statistically significant (p < 0.01). At t2, the xylitol group children with a salivary MS concentration >105 and those with ≤105 showed significantly lower AUC5.7 and AUC6.2 values than the control group. These results suggest that the long-term use of high-dose non-sucrose chewing gums had beneficial effects on plaque pH, and that this effect was statistically greater when using xylitol chewing gums, both on plaque pH and MS salivary concentration.

Item Type:Article
ID Code:7065
Status:Published
Refereed:Yes
Uncontrolled Keywords:Chewing gum, mutans streptococci, plaque pH, xylitol
Subjects:Area 06 - Scienze mediche > MED/28 Malattie odontostomatologiche
Area 06 - Scienze mediche > MED/01 Statistica medica
Divisions:001 Università di Sassari > 03 Istituti > Clinica odontoiatrica
001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Karger
eISSN:1421-976X
Deposited On:08 Feb 2012 10:50

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page