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Unbalanced rearrangement der(9;18)(p10;q10) and JAK2 V617F mutation in a patient with AML following post-polycythemic myelofibrosis

Cambosu, Francesca and Fogu, Giuseppa and Campus, Paola Maria and Fozza, Claudio and Podda, Luigi and Montella, Andrea Costantino Mario and Longinotti, Maurizio Roberto (2012) Unbalanced rearrangement der(9;18)(p10;q10) and JAK2 V617F mutation in a patient with AML following post-polycythemic myelofibrosis. Atlas of Genetics and Cytogenetics in Oncology and Haematology, Vol. 16 (1), p. 69-71. ISSN 1768-3262. Article.

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Abstract

Polycythemia Vera (PV) is a clonal myeloproliferative disorder characterized by excessive erythrocyte production, which may evolve into myelofibrosis and acute myeloid leukemia. Transformation to myelofibrosis occurs in 15-20% of cases and leukemic transformation in 5-10% of patients. The median survival time is 8-11 years and the median age at diagnosis is over 60 years. Normal karyotype is present at diagnosis in the majority of patients, while during transformation several acquired chromosome anomalies are present as trisomy 9 and gains in 9p.

Item Type:Article
ID Code:7045
Status:Published
Refereed:Yes
Uncontrolled Keywords:Polycythemia Vera (PV), myelofibrosis, AML
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Area 05 - Scienze biologiche > BIO/18 Genetica
Area 05 - Scienze biologiche > BIO/16 Anatomia umana
Divisions:001 Università di Sassari > 03 Istituti > Ematologia
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:INIST-CNRS
ISSN:1768-3262
Copyright Holders:© 2012 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Deposited On:31 Jan 2012 16:20

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