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Comparison of antibacterial activity of natural and hydroformylated essential oil of Thymus capitatus growing wild in North Sardinia with commercial Thymus essential oils

Usai, Marianna and Foddai, Marzia and Sechi, Barbara and Juliano, Claudia Clelia Assunta and Marchetti, Mauro (2010) Comparison of antibacterial activity of natural and hydroformylated essential oil of Thymus capitatus growing wild in North Sardinia with commercial Thymus essential oils. Natural Product Communications, Vol. 5 (12), p. 1985-1989. eISSN 1555-9475. Article.

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Abstract

Thymus capitatus growing wild in Sardinia showed different essential oil composition if grown surrounding Cagliari than in north Sardinia. Here we verify the composition and antimicrobial activity of the oil to make it suitable for the cosmetic and confectionery industries. With the aim of improving the scent and the antimicrobical activity of T. capitatus essential oil, a hydroformylation reaction was carried out to transform the unsaturated components of the oil into the corresponding aldehydes. The essential oil of T. capitatus exhibited a significant antibacterial activity (MIC 0.125-0.5 mg/mL), and was also found effective on C. albicans (MIC 0.125 mg/mL). After hydroformylation, several new irregular terpenoid aldehydes were detected. The perfume of the new terpenic-like aldehydes is very agreeable and, therefore, the acceptability of the aroma is remarkably improved, but the antimicrobial activity was not increased.

Item Type:Article
ID Code:7036
Status:Published
Refereed:Yes
Uncontrolled Keywords:Thymus capitatus, essential oil, hydroformylation, antibacterial activity, carvacrol
Subjects:Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Area 05 - Scienze biologiche > BIO/15 Biologia farmaceutica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di chimica biomolecolare, Sassari
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Natural Product Inc.
eISSN:1555-9475
Deposited On:30 Jan 2012 09:50

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