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The Multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease

Dolei, Antonina and Perron, Hervé (2009) The Multiple sclerosis-associated retrovirus and its HERV-W endogenous family: a biological interface between virology, genetics, and immunology in human physiology and disease. Journal of Neurovirology, Vol. 15 (1), p. 4-13. eISSN 1538-2443. Article.

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DOI: 10.1080/13550280802448451

Abstract

This mini-review summarizes current knowledge of MSRV (multiple sclerosis-associated retrovirus), founder member of the type W family of human endogenous retroviruses (HERVs), its pathogenic potential and association with diseases. As retrotransposable elements, HERVs behave differently from stable genes, and cannot be studied with "Mendelian genetics" concepts only. They also display complex interactions with other HERV families, and with classical viruses. These concepts may contribute to unravelling the etiopathogenesis of complex diseases such as multiple sclerosis, schizophrenia, and other chronic multifactorial diseases.

Item Type:Article
ID Code:6976
Status:Published
Refereed:Yes
Uncontrolled Keywords:Endogenous retroviruses, HERV-W, MSRV, multiple sclerosis, schizophrenia, syncytin
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Springer
eISSN:1538-2443
Deposited On:17 Jan 2012 11:06

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