Biino, Ginevra and Gasparini, Paolo and D'Adamo, Pio and Ciullo, Marina and Nutile, Teresa and Toniolo, Daniela and Sala, Cinzia and Minelli, Cosetta and Gögele, Martin and Balduini, Carlo L. (2012) Influence of age, sex and ethnicity on platelet count in five Italian geographic isolates: mild thrombocytopenia may be physiological. British Journal of Haematology, Vol. 157 (3), p. 384-387. eISSN 1365-2141. Article.
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Two population-based studies recently identified a high prevalence of unexplained thrombocytopenia, especially in men and older people (Biino et al, 2011; Santimone et al, 2011). Moreover, these studies reported a wide variability in the prevalence of thrombocytopenia in different villages. Further investigation concluded that the development of thrombocytopenia derived from the interaction of three factors: genetic factors, which set the ‘basic’ platelet count, gender-related factors, which result in lower platelet count in men and age-related factors, which are responsible for a progressive decrease in the platelet count over a life-time (Biino et al, 2011).
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