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Influence of age, sex and ethnicity on platelet count in five Italian geographic isolates: mild thrombocytopenia may be physiological

Biino, Ginevra and Gasparini, Paolo and D'Adamo, Pio and Ciullo, Marina and Nutile, Teresa and Toniolo, Daniela and Sala, Cinzia and Minelli, Cosetta and Gögele, Martin and Balduini, Carlo L. (2012) Influence of age, sex and ethnicity on platelet count in five Italian geographic isolates: mild thrombocytopenia may be physiological. British Journal of Haematology, Vol. 157 (3), p. 384-387. eISSN 1365-2141. Article.

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DOI: 10.1111/j.1365-2141.2011.08981.x

Abstract

Two population-based studies recently identified a high prevalence of unexplained thrombocytopenia, especially in men and older people (Biino et al, 2011; Santimone et al, 2011). Moreover, these studies reported a wide variability in the prevalence of thrombocytopenia in different villages. Further investigation concluded that the development of thrombocytopenia derived from the interaction of three factors: genetic factors, which set the ‘basic’ platelet count, gender-related factors, which result in lower platelet count in men and age-related factors, which are responsible for a progressive decrease in the platelet count over a life-time (Biino et al, 2011).

Item Type:Article
ID Code:6923
Status:Published
Refereed:Yes
Uncontrolled Keywords:Geographic isolates, platelet count, thrombocytopenia
Subjects:Area 05 - Scienze biologiche > BIO/18 Genetica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di genetica delle popolazioni, Alghero
Publisher:Blackwell / Wiley
eISSN:1365-2141
Deposited On:03 Jan 2012 16:15

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