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Characterization of OAR1 and OAR18 QTL associated with muscle depth in British commercial terminal sire sheep

Matika, Oswald and Sechi, Stefania and Pong-Wong, Ricardo and Houston, Ross D. and Clop, Alex and Wooliams, John A. and Bishop, Stephen C. (2011) Characterization of OAR1 and OAR18 QTL associated with muscle depth in British commercial terminal sire sheep. Animal Genetics, Vol. 42 (2), p. 172-180. eISSN 1365-2052. Article.

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DOI: 10.1111/j.1365-2052.2010.02121.x

Abstract

This study aimed at verifying previously identified QTL affecting growth and carcass traits on ovine chromosome 18 (OAR18) in Texel sheep (n = 1844), and on OAR1 in Charollais (n = 851) and Suffolk (n = 998) sheep. The QTL were investigated using regression and variance component mapping (VCA) of body weight, muscle and fat depth measurements. In addition, the mode of inheritance of the Texel OAR18 QTL was explored, using data from 4376 Texel sheep, fitting VCA models testing for additive and imprinting effects. We also simulated a 480-sheep population with different QTL imprinting models and various available levels of marker information to understand the behaviour of the VCA results under different assumed genetic models. In summary, the previously identified QTL were successfully verified using both interval mapping and VCA in the three breeds. We propose a polar overdominance mode of inheritance for the OAR18 QTL in Texel sheep, and we present methods to dissect the QTL mode of inheritance, using the Texel OAR18 QTL as an example.

Item Type:Article
ID Code:6920
Status:Published
Refereed:Yes
Uncontrolled Keywords:imprinting, lamb, musculature, polar overdominance, quantitative trait loci (QTL)
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/06 Parassitologia e malattie parassitarie degli animali
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > AGRIS Sardegna, Olmedo > Dipartimento per la ricerca nelle produzioni animali > Settore genetica e biotecnologie
Publisher:Blackwell / Wiley
eISSN:1365-2052
Copyright Holders:© 2010 University of Edinburgh, Animal Genetics © 2010 Stichting International Foundation for Animal Genetics
Deposited On:03 Jan 2012 10:12

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