Fozza, Claudio and Contini, Salvatore and Virdis, Patrizia and Galleu, Antonio and Massa, Antonella and Bonfigli, Silvana and Longinotti, Maurizio Roberto (2012) Patients with myelodysplastic syndromes show reduced frequencies of CD4+ CD8+ double-positive T cells. European Journal of Haematology, Vol. 88 (1), p. 89-90. eISSN 1600-0609. Article.
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Even though the expression of CD4 and CD8 on thymocytes is considered mutually exclusive, CD4+ CD8+ double-positive T cells (DP) represent a small subset of T lymphocytes that have been described in the peripheral blood of normal individuals, as well as in some pathological conditions. In particular, an agedependent accumulation of monoclonal DP has been shown in elderly healthy subjects. From the functional point of view, DP are able to act as differentiated effector memory cells with specific antiviral functions.
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