Patients with myelodysplastic syndromes show reduced frequencies of CD4+ CD8+ double-positive T cells

Patients with myelodysplastic syndromes show reduced frequencies of CD4⁺ CD8⁺ double-positive T cells

Fozza, Claudio and Contini, Salvatore and Virdis, Patrizia and Galleu, Antonio and Massa, Antonella and Bonfigli, Silvana and Longinotti, Maurizio Roberto (2012) Patients with myelodysplastic syndromes show reduced frequencies of CD4⁺ CD8⁺ double-positive T cells. European Journal of Haematology, Vol. 88 (1), p. 89-90. eISSN 1600-0609. Article.

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DOI: 10.1111/j.1600-0609.2011.01708.x

Abstract

Even though the expression of CD4 and CD8 on thymocytes is considered mutually exclusive, CD4⁺ CD8⁺ double-positive T cells (DP) represent a small subset of T lymphocytes that have been described in the peripheral blood of normal individuals, as well as in some pathological conditions. In particular, an agedependent accumulation of monoclonal DP has been shown in elderly healthy subjects. From the functional point of view, DP are able to act as differentiated effector memory cells with specific antiviral functions.

Item Type:	Article
ID Code:	6899
Status:	Published
Refereed:	Yes
Uncontrolled Keywords:	Myelodysplastic syndromes (MDS), Myeloproliferative syndrome (MPD), double-positive T cells (DP), WPSS criteria
Subjects:	Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:	001 Università di Sassari > 03 Istituti > Ematologia 001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:	Blackwell / Wiley
eISSN:	1600-0609
Deposited On:	29 Dec 2011 08:42

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