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Acetaldehyde-reinforcing effects: a study on oral self-administration behavior

Peana, Alessandra Tiziana and Muggironi, Giulia and Diana, Marco (2010) Acetaldehyde-reinforcing effects: a study on oral self-administration behavior. Frontiers in Psychiatry, Vol. 1 (23), p. 1-6. eISSN 1664-0640. Article.

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DOI: 10.3389/fpsyt.2010.00023

Abstract

Acetaldehyde (ACD) is the first metabolite of ethanol. Although, the role of ACD in ethanol addiction has been controversial, there are data showing a relationship. The objective of the current study was to further test the hypothesis that ACD itself is reinforcing. For this reason, we carried out a study on operant oral ACD self-administration. Wistar rats were trained to self-administer tap water or ACD by nose-poking in daily 30 min sessions for 15 consecutive days. Response on active nose-poke caused delivery of ACD solution or tap water, whereas responses on inactive nose-poke had no consequences. The results show that ACD maintains oral self-administration behavior and rates of active nose-pokes significantly higher than tap water. The dose–response plot for oral ACD self-administration is a “bell-shaped” curve suggesting reinforcing properties only in a limited range of doses. Furthermore, rats self-administering ACD show a deprivation effect upon ACD removal and gradually reinstated active nose-poke response when ACD was reintroduced. Overall, this study shows that ACD is orally self-administered and further supports the hypothesis that ACD possesses reinforcing properties, which suggests that some of the pharmacological effects attributed to ethanol may result from its biotransformation into ACD, thereby supporting an active involvement of ACD in ethanol addiction.

Item Type:Article
ID Code:6853
Status:Published
Refereed:Yes
Uncontrolled Keywords:Acetaldehyde, reinforcing effects, oral self-administration behavior, Wistar rats
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Frontiers Research Foundation
eISSN:1664-0640
Copyright Holders:© 2010 Peana, Muggironi, and Diana.
Additional Information:Art. Open Access.
Deposited On:13 Dec 2011 13:01

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