Cottoni, Francesca Maria Giovanna and Bolognini, Silvia and Deplano, Angelo and Garrucciu, Giovanni and Manzoni, Noemi Elisabetta and Careddu, Giovanna Francesca and Montesu, Maria Antonia and Tocco, Andreina and Lissia, Amelia and Solinas, Antonio (2004) Skin reaction in antiviral therapy for chronic hepatitis C: a role for polyethylene glycol interferon? Acta Dermato-Venereologica, Vol. 84 (2), p. 120-123. eISSN 1651-2057. Article.
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In the past decade, different modalities of antiviral therapy have been adopted aimed at eradicating hepatitis C virus infection. Initially, interferon was used in monotherapy, then interferon combined with ribavirin and amantadine. Recently, interferon has been conjugated with polyethylene glycol to allow optimization of its pharmacokinetic properties and to improve its antiviral activity. This study focused on the characteristics of the skin reactions that we observed in 27 patients with naïve hepatitis C who received polyethylene glycol interferon-ribavirin-amantadine or polyethylene glycol interferon-ribavirin and in 10 previous non-responders to interferon monotherapy who were retreated with triple therapy. In 9 patients (7 on triple therapy) dermatitis-like lesions were observed, and in 5 the severity of the lesions necessitated withdrawal from therapy.
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