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Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, Ion channels and transcranial magnetic stimulation

Addolorato, Giovanni and Leggio, Lorenzo and Woodward Hopf, Frederic and Diana, Marco and Bonci, Antonello (2012) Novel therapeutic strategies for alcohol and drug addiction: focus on GABA, Ion channels and transcranial magnetic stimulation. Neuropsychopharmacology, Vol. 37 (1), p. 163-177. eISSN 1740-634X. Article.

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DOI: 10.1038/npp.2011.216

Abstract

Drug addiction represents a major social problem where addicts and alcoholics continue to seek and take drugs despite adverse social, personal, emotional, and legal consequences. A number of pharmacological compounds have been tested in human addicts with the goal of reducing the level or frequency of intake, but these pharmacotherapies have often been of only moderate efficacy or act in a sub-population of humans. Thus, there is a tremendous need for new therapeutic interventions to treat addiction. Here, we review recent interesting studies focusing on gamma-aminobutyric acid receptors, voltage-gated ion channels, and transcranial magnetic stimulation. Some of these treatments show considerable promise to reduce addictive behaviors, or the early clinical studies or pre-clinical rationale suggest that a promising avenue could be developed. Thus, it is likely that within a decade or so, we could have important new and effective treatments to achieve the goal of reducing the burden of human addiction and alcoholism.

Item Type:Article
ID Code:6839
Status:Published
Refereed:Yes
Uncontrolled Keywords:Drug addiction, GABA, Ion channels, transcranial magnetic stimulation
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Nature Publishing Group
eISSN:1740-634X
Deposited On:09 Dec 2011 10:29

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