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Proprietà fisiologiche della corteccia motoria facciale nell'uomo: studio dei circuiti intracorticali facilitatori ed inibitori e modulazione della plasticità sinaptica

Pilurzi, Giovanna (2012) Proprietà fisiologiche della corteccia motoria facciale nell'uomo: studio dei circuiti intracorticali facilitatori ed inibitori e modulazione della plasticità sinaptica. Doctoral Thesis.

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Abstract

Physiology of corticofacial motor system and the role of facial intracortical circuits are controversial and neither sensorimotor integration nor LTP-like plasticity has been investigated in these muscles. We investigated properties of motor responses (MEP) evoked by trasncranial magnetic stimulation (TMS) of the facial motor cortex, short interval intracortical inhibition (SICI), intracortical facilitation (ICF), short-afferent inhibition (SAI) and effects of paired associative stimulation (PAS) in relaxed and active depressor angulis oris muscle (DAO). SICI and ICF were tested using paired-pulse TMS. SAI was tested by pairing facial nerve electrical stimulation with TMS of the facial motor cortex. Resting and active MEPs were acquired before and after 0-30 min from PAS delivery. SICI and ICF were significant (p < 0.001) in both relaxed and active DAO. SAI was absent in both resting and active condition, but PAS protocol significantly (p < 0.01) facilitated the resting DAO MEPs at all post-PAS times tested. Data showed that cortico-facial projection is bilateral and symmetric, with a contralateral predominance. SICI and ICF work in the facial motor cortex in both resting and active conditions. In addition, despite SAI appearing to be ineffective in FM, evidence was provided for LTP-like plasticity in the facial area.

Item Type:Doctoral Thesis
ID Code:6803
Contributors:Deriu, Franca
Publisher:Università degli studi di Sassari
Uncontrolled Keywords:Plasticità, muscoli facciali, TMS, eccitabilità corticale
Subjects:Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Cicli, scuole e corsi:Ciclo 24 > Scuole > Scienze biomediche > Fisiologia, farmacologia, morfologia e fisiopatologia del sistema nervoso
Deposited On:27 Mar 2012 12:56

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