UnissResearch

Logo Universitàegli studi di Sassari
titoli, abstracts, parole chiave >>>
Inflammatory cytokine expression is associated with Chikungunya virus resolution and symptom severity

Kelvin, Alyson A. and Banner, David and Silvi, Giuliano and Moro, Maria Luisa and Spataro, Nadir and Gaibani, Paolo and Cavrini, Francesca and Pierro, Anna Maria and Rossini, Giada and Cameron, Mark J. and Bermejo Martín, Jesús F. and Paquette, Stéphane G. and Xu, Luoling and Danesh, Ali and Farooqui, Amber and Borghetto, Ilaria and Kelvin, David J. and Sambri, Vittorio and Rubino, Salvatore (2011) Inflammatory cytokine expression is associated with Chikungunya virus resolution and symptom severity. PLoS Negleted Tropical Diseases, Vol. 5 (8), e1279. eISSN 1935-2735. Article.

[img]
Preview
Full text disponibile come PDF Richiede visualizzatore di PDF come GSview, Xpdf o Adobe Acrobat Reader
Available under License Creative Commons Attribution.

910Kb

DOI: 10.1371/journal.pntd.0001279

Abstract

The Chikungunya virus infection zones have now quickly spread from Africa to parts of Asia, North America and Europe. Originally thought to trigger a disease of only mild symptoms, recently Chikungunya virus caused large-scale fatalities and widespread economic loss that was linked to recent virus genetic mutation and evolution. Due to the paucity of information on Chikungunya immunological progression, we investigated the serum levels of 13 cytokines/chemokines during the acute phase of Chikungunya disease and 6- and 12-month post-infection follow-up from patients of the Italian outbreak. We found that CXCL9/MIG, CCL2/MCP-1, IL-6 and CXCL10/IP-10 were significantly raised in the acute phase compared to follow-up samples. Furthermore, IL-1β, TNF-α, Il-12, IL-10, IFN-γ and IL-5 had low initial acute phase levels that significantly increased at later time points. Analysis of symptom severity showed association with CXCL9/MIG, CXCL10/IP-10 and IgG levels. These data give insight into Chikungunya disease establishment and subsequent convalescence, which is imperative to the treatment and containment of this quickly evolving and frequently re-emerging disease.

Item Type:Article
ID Code:6579
Status:Published
Refereed:Yes
Uncontrolled Keywords:Chikungunya virus (CHIKV), immunological progression, cytokines
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
002 Altri enti e centri di ricerca del Nord Sardegna > Porto Conte Ricerche, Alghero
Publisher:Public Library of Science
eISSN:1935-2735
Copyright Holders:© 2011 Kelvin et al.
Deposited On:17 Nov 2011 11:47

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page