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Mammography and ultrasound imaging of preinvasive and invasive canine spontaneous mammary cancer and their similarities to human breast cancer

Mohammed, Sulma Ibrahim and Meloni, Giovanni Battista and Pinna Parpaglia, Maria Luisa and Marras, Vincenzo and Burrai, Giovanni P. and Meloni, F. and Pirino, Salvatore and Antuofermo, Elisabetta (2011) Mammography and ultrasound imaging of preinvasive and invasive canine spontaneous mammary cancer and their similarities to human breast cancer. Cancer Prevention Research, Vol. 4 (11), p. 1790-1798. ISSN 1940-6207. eISSN 1940-6215. Article.

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DOI: 10.1158/1940-6207.CAPR-11-0084

Abstract

Understanding the evolution of proliferative breast disease such as atypical hyperplasia and carcinoma in situ is essential for clinical management of women diagnosed with these lesions. Therefore, an animal model that faithfully represents human breast disease in every aspect from spontaneity of dysplasia onset, histopathologic features, and genetics to clinical outcome is needed. Previously, we studied canine spontaneous atypical hyperplasia and ductal carcinoma in situ (low, intermediate, and high grade) and reported their similarities to human lesions in histopathologic and molecular features as well as prevalence. To further validate the resemblance of these lesions to humans, we examined their mammographic and sonographic characteristics in comparison with those of human’s as well as the potential of the human Breast Imaging Reporting and Data System (BI-RADS) to predict canine disease. Nonlesional, benign, and malignant mammary glands of dogs presented to Sassari Veterinary Hospital were imaged using mammography and ultrasonography. The images where then analyzed and statistically correlated with histopathologic findings and to their similarities to humans. Our results showed that canine mammary preinvasive lesions, benign, and malignant tumors have mammographic abnormalities, including the presence, pattern, and distribution of macrocalcification and microcalcification, similar to their human counterparts. BI-RADS categorization is an accurate predictor of mammary malignancy in canine, with 90% sensitivity and 82.8% specificity. The similarities of mammographic images and the ability of BI-RADS to predict canine mammary malignances with high specificity and sensitivity further confirm and strengthen the value of dog as a model to study human breast premalignancies for the development of prognostic biomarkers.

Item Type:Article
ID Code:6577
Status:Published
Refereed:Yes
Uncontrolled Keywords:Animal tissue, breast cancer, diagnostic accuracy, histopathology
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/08 Clinica medica veterinaria
Area 06 - Scienze mediche > MED/36 Diagnostica per immagini e radioterapia
Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:001 Università di Sassari > 03 Istituti > Scienze radiologiche
001 Università di Sassari > 03 Istituti > Anatomia patologica
Publisher:American Association for Cancer Research
ISSN:1940-6207
eISSN:1940-6215
Copyright Holders:© 2011 AACR
Deposited On:23 Nov 2011 12:10

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