titoli, abstracts, parole chiave >>>
Infectious diseases and autoimmunity

Delogu, Lucia Gemma and Deidda, Silvia and Delitala, Giuseppe and Manetti, Roberto (2011) Infectious diseases and autoimmunity. The Journal of Infection in Developing Countries, Vol. 5 (10), p. 679-687. ISSN 1972-2680. Article.

[img]
Preview
Full text disponibile come PDF Richiede visualizzatore di PDF come GSview, Xpdf o Adobe Acrobat Reader
Available under License Creative Commons Attribution.

325Kb

Alternative URLs:

Abstract

Introduction: Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the development of autoimmune diseases.
Methodology: We searched PubMed, Cochrane, and Scopus without time limits for relevant articles.

Results: In this review, we (i) describe the ways in which an infectious agent can initiate or exacerbate autoimmunity; (ii) discuss the evidence linking certain infectious agents to autoimmune diseases in humans; and (iii) describe the animal models used to study the link between infection and autoimmunity.

Conclusions: Besides genetic predisposition to autoimmunity, viral and bacterial infections are known to be involved in the initiation and promotion of autoimmune diseases. These studies suggest that pathogens can trigger autoimmunity through molecular mimicry and their adjuvant effects during initiation of disease, and can promote autoimmune responses through bystander activation or epitope spreading via inflammation and/or superantigens.

Item Type:Article
ID Code:6574
Status:Published
Refereed:Yes
Uncontrolled Keywords:Viral infection, bacterial infection, autoreactive lymphocyte, molecular mimicry, bystander activation, epitope spreading, autoimmune disease
Subjects:Area 06 - Scienze mediche > MED/09 Medicina interna
Divisions:001 Università di Sassari > 01 Dipartimenti > Medicina clinica, sperimentale e oncologica
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:OLoeP
ISSN:1972-2680
Copyright Holders:© 2011 Delogu et al.
Deposited On:17 Nov 2011 09:34

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page