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Morphine withdrawal increases metabotropic glutamate 2/3 receptors expression in nucleus accumbens

Modafferi, Antonella M. E. and Diana, Marco and Nicoletti, Ferdinando and Scaccianoce, Sergio (2008) Morphine withdrawal increases metabotropic glutamate 2/3 receptors expression in nucleus accumbens. NeuroReport, Vol. 19 (9), p. 911-914. ISSN 0959-4965. eISSN 1473-558X. Article.

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DOI: 10.1097/WNR.0b013e3283021cc0

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Abstract

We examined the effects of chronic morphine treatment and withdrawal on the expression of metabotropic glutamate (mGlu)1, mGlu5, and mGlu2/3 receptors in the nucleus accumbens and caudate putamen. Rats received a 14-day morphine treatment (escalating doses from 10 to 140 mg/kg). Receptor density was evaluated after chronic treatment and after 1, 3, and 14 days of withdrawal. mGlu1 and mGlu5 expression in the nucleus accumbens and in the caudate putamen was not affected by any of the experimental manipulations. In contrast, mGlu2/3 receptors in the nucleus accumbens, but not in the caudate putamen, increased at day 1, 3, and 14 of withdrawal. We suggest that an increased expression of mGlu2/3 receptors in the nucleus accumbens might contribute to the symptoms of morphine withdrawal.

Item Type:Article
ID Code:6433
Status:Published
Refereed:Yes
Uncontrolled Keywords:Caudate putamen, drug addiction, metabotropic glutamate receptors, morphine withdrawal, nucleus accumbens
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Lippincott Williams & Wilkins
ISSN:0959-4965
eISSN:1473-558X
Copyright Holders:© 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins
Deposited On:31 Aug 2011 11:01

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