Serra, Pier Andrea and Desole, Maria Speranza and Rocchitta, Gaia Giovanna Maria and Migheli, Rossana and Lowry, John P. and O'Neill, Robert D. (2008) Selective and sensitive poly-ortho-phenylenediamine-shielded microsensore and biosensors for in vivo neurochemical monitoring. In: SardiniaChem 2008: giornata di studio dedicata alla chimica organica delle molecole biologicamente attive, 30 Maggio 2008, Sassari, Italia. Conference or Workshop Item.
Different methodologies are being developed, such as imaging, spectroscopy and electrochemistry, to study neurochemical dynamics in cell cultures or in intact brain [1-2]. One of these techniques involves the in-situ detection of biologically active molecules, including nitric oxide (NO) , glucose , glutamate (GLUT) [5-6] and lactate [1,7], in brain extracellular fluid (ECF), using implanted microsensors and biosensors. NO is a water-soluble free radical that readily diffuses through membranes and its actions in the CNS are largely studied.
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