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Noncirrhotic portal hypertension in HIV-infected patients: unique clinical and pathological findings

Vispo, Maria Eugenia and Moreno, Alberto and Maida, Ivana Rita and Barreiro, Pablo and Cuevas, Adrián and Albertos, Sonia and Soriano, Vincent (2010) Noncirrhotic portal hypertension in HIV-infected patients: unique clinical and pathological findings. AIDS, Vol. 24 (8), p. 1171-1176. ISSN 0269-9370. Article.

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DOI: 10.1097/QAD.0b013e3283389e26

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Abstract

Background: Liver disease of unknown cause in HIV-infected persons is rare but increasingly being reported. Noncirrhotic portal hypertension is the main feature in a subset of these patients, in whom gastrointestinal bleeding is the most frequent and potentially life-threatening clinical presentation.
Methods: We describe the epidemiological, clinical and histological features of 12 HIV-positive individuals presenting with noncirrhotic portal hypertension.
Results: An interpretable liver biopsy was available in 11, and cirrhosis was absent in all patients. Three patients had nodular regenerative hyperplasia of the liver, whereas eight showed morphological features previously described as ‘hepatoportal sclerosis’. In four of the later group, a distinctive lesion was noted characterized by massive absence of portal veins along with focal fibrous obliteration of small portal veins. All patients had been treated with didanosine for long periods and inflammatory and thrombotic processes hypothetically triggered by this purine analogue in the hepatic microvasculature might result in this form of obliterative portal venopathy.
Conclusion: Noncirrhotic portal hypertension is a rare but unique entity presenting in HIV-positive individuals generally with prior prolonged exposure to didanosine, which shows an obliteration of portal veins as the most distinctive histological finding in the liver.

Item Type:Article
ID Code:6426
Status:Published
Refereed:Yes
Uncontrolled Keywords:Didanosine, HIV, liver, noncirrhotic portal hypertension, portal hypertension
Subjects:Area 06 - Scienze mediche > MED/17 Malattie infettive
Divisions:001 Università di Sassari > 03 Istituti > Malattie infettive e parassitarie
Publisher:Lippincott Williams & Wilkins
ISSN:0269-9370
Copyright Holders:© 2010 Lippincott Williams & Wilkins
Deposited On:30 Aug 2011 12:23

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